RENAL-SELECTIVE PRODRUGS FOR THE TREATMENT OF HYPERTENSION - Patent 0484437

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(11)

EP 0 484 437 A1

(12)

(43)	Date of publication:
	13.05.1992 Bulletin 1992/20

(21)	Application number: 90912307.0

(22)	Date of filing: 25.07.1990

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International Patent Classification (IPC):

A61K 31/ 16^{( . )}
A61K 31/ 18^{( . )}
A61K 31/ 198^{( . )}
A61K 31/ 34^{( . )}
A61K 31/ 38^{( . )}
A61K 31/ 40^{( . )}
A61K 45/ 00^{( . )}
A61P 9/ 12^{( . )}
C07C 59/ 64^{( . )}
C07C 237/ 04^{( . )}
C07C 237/ 22^{( . )}
C07C 309/ 02^{( . )}
C07D 209/ 08^{( . )}
C07D 209/ 34^{( . )}
C07D 213/ 50^{( . )}
C07D 213/ 73^{( . )}
C07D 213/ 81^{( . )}
C07D 215/ 22^{( . )}
C07D 233/ 54^{( . )}
C07D 233/ 90^{( . )}
C07D 241/ 42^{( . )}
C07D 263/ 58^{( . )}
C07D 285/ 14^{( . )}
C07D 307/ 52^{( . )}
C07D 333/ 20^{( . )}
C07D 333/ 58^{( . )}

A61K 31/ 165^{( . )}
A61K 31/ 195^{( . )}
A61K 31/ 275^{( . )}
A61K 31/ 341^{( . )}
A61K 31/ 381^{( . )}
A61K 31/ 47^{( . )}
A61P 7/ 10^{( . )}
A61P 43/ 00^{( . )}
C07C 59/ 90^{( . )}
C07C 237/ 12^{( . )}
C07C 271/ 38^{( . )}
C07C 311/ 13^{( . )}
C07D 209/ 20^{( . )}
C07D 213/ 44^{( . )}
C07D 213/ 65^{( . )}
C07D 213/ 80^{( . )}
C07D 213/ 86^{( . )}
C07D 215/ 227^{( . )}
C07D 233/ 88^{( . )}
C07D 235/ 30^{( . )}
C07D 241/ 44^{( . )}
C07D 265/ 36^{( . )}
C07D 307/ 46^{( . )}
C07D 309/ 40^{( . )}
C07D 333/ 22^{( . )}
C07D 333/ 66^{( . )}

(86)	International application number:
	PCT/US1990/004168

(87)	International publication number:
	WO 1991/001724 (21.02.1991 Gazette 1991/05)

(84)	Designated Contracting States:
	AT BE CH DE DK ES FR GB IT LI LU NL SE

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Priority:

27.07.1989 US 19890386527

(71)	Applicant: G.D. Searle & Co.
	Chicago Illinois 60680 (US)

(72)	Inventors:
	REITZ, David, B. Chesterfield, MO 63017 (US) KOEPKE, John, P. St. Louis, MO 63144 (US) BLAINE, Edward, H. University City, MO 63130 (US) SCHUH, Joseph, R. St. Louis, MO 63100 (US) MANNING, Robert, E. St. Louis, MO 63131 (US) SMITS, Glenn, J. Ellisville, MO 63011 (US)

(74)	Representative: Beil, Walter, Dr.
	BEIL, WOLFF & BEIL Rechtsanwälte Adelonstrasse 58 D-65929 Frankfurt D-65929 Frankfurt (DE)

(54)	RENAL-SELECTIVE PRODRUGS FOR THE TREATMENT OF HYPERTENSION