(19)

(11)

EP 0 485 517 A1

(12)

(43) Date of publication: 20.05.1992 Bulletin 1992/21 (21) Application number: 90913322.0 (22) Date of filing: 02.08.1990

(51) International Patent Classification (IPC):  C07H 1/ 00( . ) C07H 9/ 04( . ) C07H 15/ 207( . ) C07H 17/ 04( . ) C07J 17/ 00( . ) C07H 3/ 06( . ) C07H 15/ 04( . ) C07H 15/ 252( . ) C07H 19/ 01( . ) (86) International application number: PCT/US1990/004338 (87) International publication number: WO 1991/002739 (07.03.1991 Gazette 1991/06)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB IT LI LU NL SE (30) Priority: 11.08.1989 US 19890392753 11.08.1989 US 19890392793 11.08.1989 US 19890392796 11.08.1989 US 19890392803 (71) Applicant: YALE UNIVERSITY New Haven, CT 06510 (US)	(72) Inventor: DANISHEFSKY, Samuel, J. New Haven, CT 06515 (US) (74) Representative: Hirsch, Marc-Roger  Cabinet Hirsch 34 rue de Bassano F-75008 Paris F-75008 Paris (FR)