(19)

(11)

EP 0 486 529 A1

(12)

(43) Date of publication: 27.05.1992 Bulletin 1992/22 (21) Application number: 90911542.0 (22) Date of filing: 15.08.1990

(51) International Patent Classification (IPC):  A61K 9/ 70( . ) A61K 47/ 10( . ) A61K 47/ 14( . ) A61K 31/ 21( . ) A61K 47/ 12( . ) A61K 47/ 22( . ) (86) International application number: PCT/US1990/004456 (87) International publication number: WO 1991/002553 (07.03.1991 Gazette 1991/06)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB IT LI LU NL SE (30) Priority: 17.08.1989 US 19890395119 (71) Applicant: SCHERING CORPORATION Kenilworth, NJ 07030 (US)	(72) Inventors: GOVIL, Sharad, K. Plantation, FL 33322 (US) RUDNIC, Edward, M. Boca Raton, FL 33433 (US) STERNER, Dale, G. Pembroke Pines, FL 33025 (US) (74) Representative: von Kreisler, Alek, Dipl.-Chem.  Patentanwälte von Kreisler-Selting-Werner Postfach 10 22 41 D-50462 Köln D-50462 Köln (DE)