(19)

(11)

EP 0 487 706 A1

(12)

(43) Date of publication: 03.06.1992 Bulletin 1992/23 (21) Application number: 91912397.0 (22) Date of filing: 06.06.1991

(51) International Patent Classification (IPC):  A61B 5/ 0452( . ) A61N 1/ 08( . ) G06F 17/ 00( . ) A61B 10/ 00( . ) A61N 1/ 39( . ) (86) International application number: PCT/US1991/004000 (87) International publication number: WO 1991/019452 (26.12.1991 Gazette 1991/29)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IT LI LU NL SE (30) Priority: 20.06.1990 US 19900541881 17.05.1991 US 19910701753 (71) Applicant: Cedars-Sinai Medical Center Los Angeles, California 90048-0750 (US)	(72) Inventors: KARAGUEUZIAN, Hrayr, Sevag Los Angeles, CA 91607 (US) DIAMOND, George, Alexander Los Angeles, CA 90068 (US) KHAN, Steven, Shahid Los Angeles, CA 90064 (US) DENTON, Timothy, Alan Los Angeles, CA 90048 (US) EVANS, Steven New York, NY 20022 (US) (74) Representative: Williams, Trevor John  J.A. KEMP & CO. 14 South Square Gray's Inn London WC1R 5LX London WC1R 5LX (GB)