(19)

(11)

EP 0 489 830 A1

(12)

(43) Date of publication: 17.06.1992 Bulletin 1992/25 (21) Application number: 90913470.0 (22) Date of filing: 29.08.1990

(51) International Patent Classification (IPC):  A61K 38/ 16( . ) C07K 14/ 00( . ) C12N 1/ 15( . ) C12N 1/ 21( . ) C12N 5/ 06( . ) C12N 15/ 09( . ) C12P 21/ 02( . ) C12R 1/ 91( . ) A61K 48/ 00( . ) C07K 14/ 81( . ) C12N 1/ 19( . ) C12N 5/ 00( . ) C12N 5/ 10( . ) C12N 15/ 15( . ) A61K 38/ 00( . ) (86) International application number: PCT/DK1990/000225 (87) International publication number: WO 1991/003557 (21.03.1991 Gazette 1991/07)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB IT LI LU NL SE (30) Priority: 29.08.1989 DK 19890004235 29.08.1989 DK 19890004236 29.08.1989 DK 19890004237 (71) Applicant: NOVO NORDISK A/S DK-2880 Bagsvaerd (DK)	(72) Inventors: ESPER, Boel DK-2840 Holte (DK) LARS, Sottrup-Jensen DK-8230 Abyhoj (DK) (74) Representative: Jensen, Bo Hammer, et al  c/o Novo Nordisk A/S Novo Allé DK-2880 Bagsvaerd DK-2880 Bagsvaerd (DK)