(19)

(11)

EP 0 489 868 A1

(12)

(43) Date of publication: 17.06.1992 Bulletin 1992/25 (21) Application number: 90914595.0 (22) Date of filing: 14.09.1990

(51) International Patent Classification (IPC):  A01K 67/ 027( . ) C12N 15/ 85( . ) C07K 14/ 73( . ) (86) International application number: PCT/US1990/005248 (87) International publication number: WO 1991/004327 (04.04.1991 Gazette 1991/08)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB IT LI LU NL SE (30) Priority: 15.09.1989 US 19890407932 (71) Applicant: TSI Corporation Worcester, Massachusetts 01605 (US)	(72) Inventor: WEI, Cha-Mer Worcester, MA 01604 (US) (74) Representative: Bassett, Richard Simon, et al  ERIC POTTER & CLARKSON St. Mary's Court St. Mary's Gate Nottingham NG1 1LE Nottingham NG1 1LE (GB)