(19)

(11)

EP 0 490 897 A1

(12)

(43) Date of publication: 24.06.1992 Bulletin 1992/26 (21) Application number: 90907932.0 (22) Date of filing: 05.03.1990

(51) International Patent Classification (IPC):  A61K 49/ 00( . ) C07D 257/ 00( . ) C07F 1/ 08( . ) C07F 11/ 00( . ) C07F 15/ 02( . ) A61K 49/ 06( . ) C07D 295/ 12( . ) C07F 5/ 00( . ) C07F 13/ 00( . ) (86) International application number: PCT/US1990/001196 (87) International publication number: WO 1991/003261 (21.03.1991 Gazette 1991/07)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB IT LI LU NL SE (30) Priority: 05.09.1989 US 19890402623 (71) Applicant: MALLINCKRODT, INC. St. Louis, MO 63134 (US)	(72) Inventors: RAJAGOPALAN, Raghavan Maryland Heights, MO 63043 (US) PERIASAMY, Muthunadar Creve Coeur, MO 63146 (US) (74) Representative: Eyles, Christopher Thomas  W.P. THOMPSON & CO. Celcon House 289-293 High Holborn London WC1V 7HU London WC1V 7HU (GB)