(19)

(11)

EP 0 490 917 A1

(12)

(43) Date of publication: 24.06.1992 Bulletin 1992/26 (21) Application number: 90912752.0 (22) Date of filing: 01.09.1990

(51) International Patent Classification (IPC):  A61K 9/ 08( . ) A61K 49/ 04( . ) A61K 49/ 00( . ) (86) International application number: PCT/EP1990/001481 (87) International publication number: WO 1991/003263 (21.03.1991 Gazette 1991/07)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB IT LI LU NL SE (30) Priority: 04.09.1989 GB 19890019929 (71) Applicant: NYCOMED AS N-0401 Oslo 4 (NO)	(72) Inventors: ALM N, Torsten S-21774 Malmö (SE) B TH, Lars S-21146 Malmö (SE) KSENDAL, Audun, Nesheim N-0550 Oslo 5 (NO) (74) Representative: Cockbain, Julian, Dr.  Frank B. Dehn & Co. Imperial House 15-19 Kingsway London WC2B 6UZ London WC2B 6UZ (GB)