(19)

(11)

EP 0 490 975 A1

(12)

(43) Date of publication: 24.06.1992 Bulletin 1992/26 (21) Application number: 90913924.0 (22) Date of filing: 05.09.1990

(51) International Patent Classification (IPC):  C12N 15/ 09( . ) A61P 37/ 00( . ) C07K 14/ 705( . ) C12N 15/ 12( . ) C12R 1/ 91( . ) A61K 38/ 00( . ) C07K 14/ 00( . ) C07K 14/ 715( . ) C12P 21/ 00( . ) (86) International application number: PCT/US1990/004949 (87) International publication number: WO 1991/003555 (21.03.1991 Gazette 1991/07)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB IT LI LU NL SE (30) Priority: 07.09.1989 US 19890404179 20.03.1990 US 19900496449 (71) Applicant: SCHERING CORPORATION Kenilworth New Jersey 07033 (US)	(72) Inventors: GALIZZI, Jean-Pierre 27, chemin des Peupliers F-69572 Dardilly (FR) HARADA, Nobuyuki Palo Alto, CA 94303 (US) MAYAJIMA, Atsushi Palo Alto, CA 94306 (US) (74) Representative: Ritter, Stephen David, et al  Mathys & Squire 100 Grays Inn Road London WC1X 8AL London WC1X 8AL (GB)