(19)

(11)

EP 0 491 754 A1

(12)

(43) Date of publication: 01.07.1992 Bulletin 1992/27 (21) Application number: 90913312.0 (22) Date of filing: 29.08.1990

(51) International Patent Classification (IPC):  A61K 9/ 20( . ) A61K 47/ 14( . ) A61K 47/ 02( . ) (86) International application number: PCT/US1990/004903 (87) International publication number: WO 1991/004018 (04.04.1991 Gazette 1991/08)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB IT LI LU NL SE (30) Priority: 15.09.1989 US 19890407865 (71) Applicant: CIMA LABS, INC. Minneapolis, MN 55428 (US)	(72) Inventors: WEHLING, Fred New Hope, MN 55427 (US) SCHUEHLE, Steve Maple Grove, Minnesota 55369 (US) MADAMALA, Navayanarao Plymouth, MN 55442 (US) (74) Representative: Mossmark, Anders, et al  Albihn West AB, Box 142 S-401 22 Göteborg S-401 22 Göteborg (SE)