(19)

(11)

EP 0 491 797 A1

(12)

(43) Date of publication: 01.07.1992 Bulletin 1992/27 (21) Application number: 90913838.0 (22) Date of filing: 13.09.1990

(51) International Patent Classification (IPC):  A61K 31/ 435( . ) C07D 498/ 18( . ) C07H 19/ 01( . ) A61P 37/ 06( . ) C07D 498/ 22( . ) (86) International application number: PCT/GB1990/001412 (87) International publication number: WO 1991/004025 (04.04.1991 Gazette 1991/08)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB IT LI LU NL SE (30) Priority: 14.09.1989 GB 19890020849 15.09.1989 GB 19890020985 22.03.1990 GB 19900006449 08.06.1990 GB 19900012795 06.07.1990 GB 19900014959 (71) Applicant: FISONS plc Ipswich Suffolk IP1 1QH (GB)	(72) Inventors: DONALD, David, Keith Ashby de la Zouch Leicestershire LE6 5FE (GB) FURBER, Mark Kegworth Derby DE7 2EN (GB) HARDERN, David, Norman Loughborough Leicestershire LE12 5NP (GB) LEFF, Paul Long Whatton Leicestershire LE12 5BB (GB) (74) Representative: Wright, Robert Gordon McRae  FISONS plc 12 Derby Road Loughborough Leicestershire LE11 0BB Loughborough Leicestershire LE11 0BB (GB)