(19)

(11)

EP 0 491 853 A1

(12)

(43) Date of publication: 01.07.1992 Bulletin 1992/27 (21) Application number: 90914848.0 (22) Date of filing: 13.09.1990

(51) International Patent Classification (IPC):  A61F 13/ 02( . ) A61F 13/ 00( . ) A61K 9/ 70( . ) (86) International application number: PCT/US1990/005198 (87) International publication number: WO 1991/003998 (04.04.1991 Gazette 1991/08)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB IT LI LU NL SE (30) Priority: 14.09.1989 US 19890407476 (71) Applicant: CYGNUS THERAPEUTIC SYSTEMS Redwood City, CA 94063 (US)	(72) Inventors: CLEARY, Gary, W. San Mateo, CA 94401 (US) COLLEY, Kenneth, J. San Francisco, CA 94401 (US) MIRANDA, Jesus Miami, FL 33186 (US) CHIANG, Chia-Ming Foster City, CA 94404 (US) (74) Representative: Goldin, Douglas Michael  J.A. KEMP & CO. 14, South Square Gray's Inn London WC1R 5LX London WC1R 5LX (GB)