(19)

(11)

EP 0 491 888 A1

(12)

(43) Date of publication: 01.07.1992 Bulletin 1992/27 (21) Application number: 91910648.0 (22) Date of filing: 23.05.1991

(51) International Patent Classification (IPC):  A61K 38/ 00( . ) C07K 14/ 00( . ) C07K 16/ 00( . ) C12N 5/ 10( . ) C12N 15/ 85( . ) C12P 21/ 08( . ) A61K 39/ 00( . ) A61K 39/ 395( . ) C07K 14/ 73( . ) C07K 16/ 28( . ) C12N 15/ 09( . ) C12P 21/ 02( . ) C12Q 1/ 70( . ) C12R 1/ 91( . ) (86) International application number: PCT/US1991/003460 (87) International publication number: WO 1991/018618 (12.12.1991 Gazette 1991/28)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IT LI LU NL SE (30) Priority: 25.05.1990 US 19900529186 (71) Applicant: BIOGEN, INC. Cambridge Massachusetts 02142 (US)	(72) Inventors: FISHER, Richard, A. Brookline, MA 02146 (US) HESSION, Catherine South Weymouth, MA 02190 (US) BURKLY, Linda, C. West Newton, MA 02165 (US) (74) Representative: VOSSIUS & PARTNER  P.O. Box 86 07 67 D-81634 München D-81634 München (DE)