(19)

(11)

EP 0 493 434 A1

(12)

(43) Date of publication: 08.07.1992 Bulletin 1992/28 (21) Application number: 90913766.0 (22) Date of filing: 07.09.1990

(51) International Patent Classification (IPC):  C07K 14/ 575( . ) C07K 14/ 705( . ) C12N 1/ 21( . ) C12N 15/ 16( . ) G01N 33/ 53( . ) C07K 14/ 00( . ) C07K 14/ 72( . ) C12N 15/ 09( . ) C12P 21/ 02( . ) C12R 1/ 91( . ) (86) International application number: PCT/US1990/005066 (87) International publication number: WO 1991/003483 (21.03.1991 Gazette 1991/07)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB IT LI LU NL SE (30) Priority: 08.09.1989 US 19890404899 10.08.1990 US 19900565669 (71) Applicant: NEW ENGLAND MEDICAL CENTER HOSPITALS, INC. Boston Massachusetts 02111 (US)	(72) Inventor: CONE, Roger Roslindale, MA 02131 (US) (74) Representative: Deans, Michael John Percy, et al  Lloyd Wise, Tregear & CO. Norman House 105-109 Strand London WC2R OAE London WC2R OAE (GB)