(19)

(11)

EP 0 493 526 A1

(12)

(43) Date of publication: 08.07.1992 Bulletin 1992/28 (21) Application number: 90915689.0 (22) Date of filing: 18.09.1990

(51) International Patent Classification (IPC):  A61K 51/ 00( . ) A61K 51/ 12( . ) A61K 51/ 10( . ) (86) International application number: PCT/US1990/005313 (87) International publication number: WO 1991/004057 (04.04.1991 Gazette 1991/08)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB IT LI LU NL SE (30) Priority: 22.09.1989 US 19890411372 (71) Applicant: NEORX CORPORATION Seattle Washington 98119 (US)	(72) Inventors: VANDERHEYDEN, Jean-Luc Seattle, WA 98199 (US) FRITZBERG, Alan, R. Edmonds, WA 98020 (US) BUGAJ, Joseph, E. Bothell, WA 98011 (US) SU, Fu-Min Seattle, WA 98125 (US) VENKATESAN, Prasanna Bothell, WA 98012 (US) (74) Representative: Strehl Schübel-Hopf Groening & Partner  Maximilianstrasse 54 D-80538 München D-80538 München (DE)