(19)

(11)

EP 0 494 140 A1

(12)

(43) Date of publication: 15.07.1992 Bulletin 1992/29 (21) Application number: 90905138.0 (22) Date of filing: 27.09.1989

(51) International Patent Classification (IPC):  C07D 307/ 91( . ) C07D 451/ 14( . ) C07D 471/ 04( . ) C07D 405/ 12( . ) C07D 453/ 02( . ) C07D 498/ 08( . ) (86) International application number: PCT/US1989/004221 (87) International publication number: WO 1991/004738 (18.04.1991 Gazette 1991/09)

(84) Designated Contracting States: AT BE CH DE FR GB IT LI LU NL SE (71) Applicant: RORER INTERNATIONAL (HOLDINGS), INC. Lewes, DE 19958 (US)

(72) Inventors: YOUSSEFYEH, Raymond, D. Princeton Junction, NJ 08550 (US) CAMPBELL, Henry, F. North Wales, PA 19454 (US) KUHLA, Donald, E. Doylestown, PA 18901 (US) AIREY, John, Edward King of Prussia, PA 19406 (US) KLEIN, Scott, Ira Audubon, PA 19403 (US) POWERS, Matthew, Ray Jeffersonville, PA 19403 (US) (74) Representative: Le Pennec, Magali, et al  RHONE-POULENC RORER SA, Direction des Brevets, 20 Avenue Raymond Aron F-92160 Antony F-92160 Antony (FR)