(19)

(11)

EP 0 494 149 A1

(12)

(43) Date of publication: 15.07.1992 Bulletin 1992/29 (21) Application number: 90911287.0 (22) Date of filing: 02.08.1990

(51) International Patent Classification (IPC):  C12N 15/ 09( . ) A23L 1/ 227( . ) C12N 9/ 52( . ) C12R 1/ 225( . ) A23L 1/ 226( . ) C12N 1/ 21( . ) C12N 15/ 57( . ) (86) International application number: PCT/EP1990/001302 (87) International publication number: WO 1991/002064 (21.02.1991 Gazette 1991/05)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB IT LI LU NL SE (30) Priority: 04.08.1989 NL 19890002010 (71) Applicant: NEDERLANDS INSTITUUT VOOR ZUIVELONDERZOEK NL-6718 ZB Ede (NL)

(72) Inventors: VOS, Petrus, Antonius, Josephina NL-6871 HZ Heelsum (NL) SIEZEN, Roelant, Jan NL-6715 KA Ede (NL) DE VOS, Willem, Meindert NL-6721 SJ Bennekom (NL) KOK, Jan NL-9715 LR Groningen (NL) VENEMA, Gerhardus NL-9751 NN Haren (NL) HAANDRIKMAN, Alfred, Jacques NL-9737 RB Groningen (NL) (74) Representative: de Bruijn, Leendert C., et al  Nederlandsch Octrooibureau P.O. Box 29720 NL-2502 LS Den Haag NL-2502 LS Den Haag (NL)