(19)

(11)

EP 0 494 237 A1

(12)

(43) Date of publication: 15.07.1992 Bulletin 1992/29 (21) Application number: 90915155.0 (22) Date of filing: 26.09.1990

(51) International Patent Classification (IPC):  C07K 16/ 00( . ) G01N 33/ 569( . ) G01N 33/ 548( . ) (86) International application number: PCT/GB1990/001476 (87) International publication number: WO 1991/005260 (18.04.1991 Gazette 1991/09)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB IT LI LU NL SE (30) Priority: 28.09.1989 GB 19890021880 (71) Applicant: MEDICAL RESEARCH COUNCIL London W1N 4AL (GB)	(72) Inventors: MILSTEIN, Cesar Cambridge CB2 2QG (GB) GHERARDI, Ermanno Cambridge CB4 3NW (GB) DREHER, Martin Cambridge CB1 4RW (GB) PANNELL, Richard Haverhill, Suffolk CB9 0BZ (GB) (74) Representative: Matthews, Heather Clare, et al  Keith W Nash & Co Pearl Assurance House 90-92 Regent Street Cambridge CB2 1DP Cambridge CB2 1DP (GB)