(19)

(11)

EP 0 495 959 A1

(12)

(43) Date of publication: 29.07.1992 Bulletin 1992/31 (21) Application number: 91914607.0 (22) Date of filing: 08.08.1991

(51) International Patent Classification (IPC):  A61K 31/ 535( . ) A61P 25/ 00( . ) C07D 265/ 18( . ) A61K 31/ 536( . ) A61P 25/ 28( . ) (86) International application number: PCT/EP1991/001505 (87) International publication number: WO 1992/002224 (20.02.1992 Gazette 1992/05)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IT LI NL SE (30) Priority: 10.08.1990 GB 19900017610 (71) Applicant: FARMITALIA CARLO ERBA S.r.l. I-20159 Milano (IT)	(72) Inventors: CACCIA, Carla I-21013 Gallarate (IT) CARFAGNA, Nicola I-20014 Nerviano (IT) FARIELLO, Ruggero I-21016 Comegna di Luino (IT) (74) Representative: Woods, Geoffrey Corlett  J.A. KEMP & CO. 14 South Square Gray's Inn London WC1R 5LX London WC1R 5LX (GB)