(19)
(11)
EP 0 496 833 A1
(12)
(43)
Date of publication:
05.08.1992
Bulletin 1992/32
(21)
Application number:
90917700.0
(22)
Date of filing:
18.10.1990
(51)
International Patent Classification (IPC):
A61K
38/
00
( . )
A61P
7/
00
( . )
C07K
14/
495
( . )
C12N
15/
09
( . )
C12R
1/
19
( . )
A61K
38/
22
( . )
A61P
43/
00
( . )
C07K
14/
52
( . )
C12P
21/
02
( . )
(86)
International application number:
PCT/US1990/006006
(87)
International publication number:
WO 1991/005565
(
02.05.1991
Gazette 1991/10)
(84)
Designated Contracting States:
AT BE CH DE DK ES FR GB GR IT LI LU NL SE
(30)
Priority:
18.10.1989
US 19890422962
(71)
Applicant:
CREATIVE BIOMOLECULES, INC.
Hopkinton Massachusetts 01478 (US)
(72)
Inventor:
COHEN, Charles, M.
Medway, MA 02053 (US)
(74)
Representative:
Holdcroft, James Gerald, Dr., et al
Graham Watt & Co., Riverhead
Sevenoaks, Kent TN13 2BN
Sevenoaks, Kent TN13 2BN (GB)
(54)
BIOSYNTHETIC CONSTRUCTS OF TGF-$g(b)