(19)

(11)

EP 0 497 866 A1

(12)

(43) Date of publication: 12.08.1992 Bulletin 1992/33 (21) Application number: 90916428.0 (22) Date of filing: 23.10.1990

(51) International Patent Classification (IPC):  A61K 38/ 00( . ) A61K 51/ 00( . ) C07K 1/ 22( . ) C07K 14/ 705( . ) C07K 16/ 28( . ) C12N 5/ 10( . ) C12N 15/ 12( . ) C12P 21/ 06( . ) C12Q 1/ 68( . ) G01N 33/ 566( . ) C12R 1/ 91( . ) A61K 39/ 395( . ) A61P 43/ 00( . ) C07K 14/ 00( . ) C07K 16/ 00( . ) C07K 19/ 00( . ) C12N 15/ 09( . ) C12P 21/ 02( . ) C12P 21/ 08( . ) G01N 33/ 53( . ) G01N 33/ 74( . ) (86) International application number: PCT/US1990/006125 (87) International publication number: WO 1991/006647 (16.05.1991 Gazette 1991/11)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IT LI LU NL SE (30) Priority: 24.10.1989 US 19890426150 05.06.1990 US 19900533659 (71) Applicants: TRITON BIOSCIENCES INC. Alameda, CA 94501 (US) NATIONAL INSTITUTES OF HEALTH Bethesda, Maryland 20892 (US)	(72) Inventors: FELDMAN, Richard, I. El Cerrito, CA 95430 (US) HARKINS, Richard, N. Alameda, CA 94501 (US) BATTEY, James, F., Jr. Bethesda, MD 20817 (US) WU, James, M. El Cerrito, CA 94530 (US) SLATTERY, Timothy, K. Mountain View, CA 94403 (US) (74) Representative: Thomson, Paul Anthony  Potts, Kerr & Co. 15, Hamilton Square Birkenhead Merseyside L41 6BR Birkenhead Merseyside L41 6BR (GB)