(19)

(11)

EP 0 498 823 A1

(12)

(43) Date of publication: 19.08.1992 Bulletin 1992/34 (21) Application number: 90915963.0 (22) Date of filing: 22.10.1990

(51) International Patent Classification (IPC):  A61M 5/ 14( . ) A61M 5/ 168( . ) (86) International application number: PCT/US1990/006060 (87) International publication number: WO 1991/006255 (16.05.1991 Gazette 1991/11)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IT LI LU NL SE (30) Priority: 30.10.1989 US 19890428960 (71) Applicant: BETH ISRAEL HOSPITAL Boston Massachusetts 02215 (US)	(72) Inventor: EMANUEL, Ezekiel Brookline, MA 02146 (US) (74) Representative: Jump, Timothy John Simon, et al  Venner Shipley & Co. 20 Little Britain London EC1A 7DH London EC1A 7DH (GB)