(19)

(11)

EP 0 498 831 A1

(12)

(43) Date of publication: 19.08.1992 Bulletin 1992/34 (21) Application number: 90916323.0 (22) Date of filing: 31.10.1990

(51) International Patent Classification (IPC):  A61M 15/ 00( . ) (86) International application number: PCT/GB1990/001665 (87) International publication number: WO 1991/006334 (16.05.1991 Gazette 1991/11)

(84) Designated Contracting States: CH DE FR GB IT LI NL (30) Priority: 03.11.1989 GB 19890024823 (71) Applicant: SMITH KLINE & FRENCH LABORATORIES LIMITED Welwyn Garden City Hertfordshire, AL7 1EY (GB)	(72) Inventors: HARE, John, Francis Welwyn Hertfordshire AL6 9AR (GB) BURNS, Colin, Peter Welwyn Hertfordshire AL 6 9AR (GB) O'CONNOR, Stephen, Anthony, Peter Potton Bedfordshire SG19 2NR (GB) (74) Representative: Thompson, Clive Beresford, et al  SmithKline Beecham plc Corporate Intellectual Property SB House Great West Road Brentford, Middlesex TW8 9BD Brentford, Middlesex TW8 9BD (GB)