(19)

(11)

EP 0 500 610 A1

(12)

(43) Date of publication: 02.09.1992 Bulletin 1992/36 (21) Application number: 90916194.0 (22) Date of filing: 06.11.1990

(51) International Patent Classification (IPC):  A61K 31/ 70( . ) A61K 31/ 7052( . ) A61K 31/ 7068( . ) A61K 31/ 7076( . ) A61P 31/ 12( . ) C07D 405/ 14( . ) C07D 473/ 34( . ) C07H 19/ 16( . ) A61K 31/ 7042( . ) A61K 31/ 7064( . ) A61K 31/ 7072( . ) A61K 31/ 708( . ) C07D 405/ 04( . ) C07D 473/ 18( . ) C07H 19/ 06( . ) (86) International application number: PCT/EP1990/001853 (87) International publication number: WO 1991/006554 (16.05.1991 Gazette 1991/11)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IT LI LU NL SE (30) Priority: 06.11.1989 GB 19890025037 06.11.1989 GB 19890025039 (71) Applicant: NYCOMED AS N-0401 Oslo 4 (NO)	(72) Inventors: KLAVENESS, Jo N-0276 Oslo 2 (NO) UNDHEIM, Kjell N-1300 Sandvika (NO) RISE, Frode S-211 31 Malmö (SE) HATLELID, Jostein N-0461 Oslo 4 (NO) (74) Representative: Matthews, Derek Peter, et al  Frank B. Dehn & Co. Imperial House 15-19 Kingsway London WC2B 6UZ London WC2B 6UZ (GB)