(19)

(11)

EP 0 500 626 A1

(12)

(43) Date of publication: 02.09.1992 Bulletin 1992/36 (21) Application number: 90916277.0 (22) Date of filing: 31.10.1990

(51) International Patent Classification (IPC):  C07K 14/ 195( . ) C12N 9/ 10( . ) C12N 15/ 31( . ) C12N 15/ 74( . ) C12R 1/ 01( . ) C12N 1/ 21( . ) C12N 15/ 09( . ) C12N 15/ 70( . ) C12P 21/ 02( . ) (86) International application number: PCT/EP1990/001838 (87) International publication number: WO 1991/006656 (16.05.1991 Gazette 1991/11)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IT LI LU NL SE (30) Priority: 03.11.1989 GB 19890024883 (71) Applicant: SHELL INTERNATIONALE RESEARCH MAATSCHAPPIJ B.V. NL-2596 HR Den Haag (NL)	(72) Inventors: CORNISH, Alexander 15 Turner Close Sittingbourne Kent ME10 2UE (GB) WILLIAMS, Steven, Geraint Flat 3 Leicester LE2 1QW (GB) JONES, Colin, William Leicester LE2 3RD (GB) LINTON, John, Dudley 16 Harvey Drive Kent ME10 4UR (GB) BETTERIDGE, Peter, Richard 3 Selby Close Kent CT6 6UN (GB) GREENWOOD, Jacqueline, Anne Leicester LE2 6GQ (GB)