(19)

(11)

EP 0 500 653 A1

(12)

(43) Date of publication: 02.09.1992 Bulletin 1992/36 (21) Application number: 90916628.0 (22) Date of filing: 12.10.1990

(51) International Patent Classification (IPC):  A61K 31/ 505( . ) A61P 35/ 00( . ) C07C 255/ 17( . ) C07C 255/ 31( . ) C07C 255/ 40( . ) C07D 207/ 34( . ) C07F 9/ 6561( . ) A61P 31/ 12( . ) A61P 43/ 00( . ) C07C 255/ 25( . ) C07C 255/ 35( . ) C07C 255/ 42( . ) C07D 487/ 04( . ) (86) International application number: PCT/US1990/005756 (87) International publication number: WO 1991/006548 (16.05.1991 Gazette 1991/11)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB IT LI LU NL SE (30) Priority: 31.10.1989 US 19890429097 31.10.1989 US 19890429098 31.10.1989 US 19890429099 31.10.1989 US 19890429100 29.11.1989 US 19890442798 (71) Applicant: BIOCRYST, INC. Birmingham, AL 35205 (US)	(72) Inventors: SECRIST, John, A., III Birmingham, AL 35243 (US) ERION, Mark, David Livingston, NJ 07039 (US) MONTGOMERY, John, A. Birmingham, AL 35223 (US) EALICK, Steven, E. Birmingham, AL 35205 (US) GUIDA, Wayne, C. Fanwood, NJ 07023 (US) NIWAS, Shri Birmingham, AL 35209 (US) (74) Representative: Stalla-Bourdillon, Bernard  CABINET NONY & CIE 29, rue Cambacérès F-75008 Paris F-75008 Paris (FR)