(19)

(11)

EP 0 500 734 A1

(12)

(43) Date of publication: 02.09.1992 Bulletin 1992/36 (21) Application number: 90917369.0 (22) Date of filing: 15.11.1990

(51) International Patent Classification (IPC):  C12N 15/ 09( . ) A61P 7/ 00( . ) C07H 21/ 04( . ) C07K 14/ 00( . ) C07K 14/ 755( . ) C07K 16/ 00( . ) C12N 5/ 10( . ) C12N 15/ 85( . ) A61K 38/ 00( . ) A61K 38/ 43( . ) A61P 7/ 02( . ) C07K 7/ 06( . ) C07K 14/ 745( . ) C07K 14/ 81( . ) C07K 19/ 00( . ) C12N 15/ 12( . ) C12P 21/ 02( . ) C12R 1/ 91( . ) (86) International application number: PCT/DK1990/000291 (87) International publication number: WO 1991/007490 (30.05.1991 Gazette 1991/12)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IT LI LU NL SE (30) Priority: 17.11.1989 US 19890438639 (60) Divisional application: 95107535.7 / 0670332 (71) Applicants: NOVO NORDISK A/S DK-2880 Bagsvaerd (DK) CHIRON CORPORATION Emeryville California 94608-2916 (US)	(72) Inventors: CHAPMAN, Barbara Berkeley, CA 94702 (US) BURKE, Rae, Lyn San Francisco, CA 94117 (US) RASMUSSEN, Mirella, Ezban DK-2100 Copenhagen (DK) MIKKELSEN, Jan, Moller DK-2820 Gentofte (DK) (74) Representative: Nilausen, Kim, et al  c/o Novo Nordisk A/S Novo Allé DK-2880 Bagsvaerd DK-2880 Bagsvaerd (DK)