(19)

(11)

EP 0 500 780 A1

(12)

(43) Date of publication: 02.09.1992 Bulletin 1992/36 (21) Application number: 91900564.0 (22) Date of filing: 13.11.1990

(51) International Patent Classification (IPC):  G01N 33/ 53( . ) G01N 33/ 50( . ) G01N 33/ 569( . ) C12Q 1/ 68( . ) G01N 33/ 564( . ) (86) International application number: PCT/US1990/006613 (87) International publication number: WO 1991/007508 (30.05.1991 Gazette 1991/12)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IT LI LU NL SE (30) Priority: 15.11.1989 US 19890437370 02.03.1990 US 19900488353 (71) Applicant: NATIONAL JEWISH CENTER FOR IMMUNOLOGY AND RESPIRATORY MEDICINE Denver, CO 80206 (US)	(72) Inventors: KOTZIN, Brian, L. Denver, CO 80207 (US) MARRACK, Philippa Denver, CO 80207 (US) KAPPLER, John Denver, CO 80207 (US) (74) Representative: Schulze Horn, Stefan, Dipl.-Ing. M.Sc.  Goldstrasse 50 D-48147 Münster D-48147 Münster (DE)