(19)

(11)

EP 0 502 099 A1

(12)

(43) Date of publication: 09.09.1992 Bulletin 1992/37 (21) Application number: 91900482.0 (22) Date of filing: 28.11.1990

(51) International Patent Classification (IPC):  A61K 39/ 00( . ) C07K 14/ 00( . ) C07K 14/ 28( . ) C07K 19/ 00( . ) C12N 5/ 02( . ) C12N 15/ 09( . ) C12R 1/ 19( . ) A61P 1/ 02( . ) C07K 14/ 195( . ) C07K 14/ 41( . ) C12N 1/ 21( . ) C12N 9/ 10( . ) C12P 21/ 02( . ) C12R 1/ 63( . ) (86) International application number: PCT/US1990/006811 (87) International publication number: WO 1991/007979 (13.06.1991 Gazette 1991/13)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IT LI LU NL SE (30) Priority: 29.11.1989 US 19890442783 (71) Applicant: CENTER FOR INNOVATIVE TECHNOLOGY Herndon, VA 22070 (US)	(72) Inventors: DERTZBAUGH, Mark, T. Richmond, VA 23224 (US) MACRINA, Francis, L. Richmond, VA 23236 (US) (74) Representative: Grünecker, Kinkeldey, Stockmair & Schwanhäusser, Anwaltssozietät  Maximilianstrasse 58 D-80538 München D-80538 München (DE)