(19)

(11)

EP 0 502 103 A1

(12)

(43) Date of publication: 09.09.1992 Bulletin 1992/37 (21) Application number: 91900512.0 (22) Date of filing: 30.11.1990

(51) International Patent Classification (IPC):  C12Q 1/ 56( . ) G01N 21/ 77( . ) G01N 33/ 86( . ) G01N 21/ 75( . ) G01N 21/ 84( . ) (86) International application number: PCT/US1990/006988 (87) International publication number: WO 1991/008460 (13.06.1991 Gazette 1991/13)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IT LI LU NL SE (30) Priority: 01.12.1989 US 19890443948 (71) Applicant: AKZO N.V. NL-6800 LS Arnhem (NL)	(72) Inventors: HOFFMAN, Julie, Frances Durham, NC 27713 (US) CALLAHAN, Janet, Black Carroboro, NC 27510 (US) SWOPE, Charles, Hermas Raleigh, NC 27613 (US) (74) Representative: Hermans, Franciscus G.M., et al  P.O. Box 20 NL-5340 BH Oss NL-5340 BH Oss (NL)