SUBSTITUTED INDOLE-, INDENE-, PYRANOINDOLE- AND TETRAHYDROCARBAZOLE- ALKANOIC ACID DERIVATIVES AS INHIBITORS OF PLA 2? AND LIPOXYGENASE - Patent 0502106

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(11)

EP 0 502 106 A1

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(43)	Date of publication:
	09.09.1992 Bulletin 1992/37

(21)	Application number: 91900547.0

(22)	Date of filing: 27.10.1990

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International Patent Classification (IPC):

A61K 31/ 085^{( . )}
A61K 31/ 12^{( . )}
A61K 31/ 215^{( . )}
A61K 31/ 343^{( . )}
A61K 31/ 381^{( . )}
A61K 31/ 403^{( . )}
A61K 31/ 47^{( . )}
A61P 37/ 08^{( . )}
C07C 51/ 353^{( . )}
C07C 67/ 343^{( . )}
C07C 69/ 757^{( . )}
C07D 209/ 22^{( . )}
C07D 277/ 24^{( . )}
C07D 333/ 56^{( . )}
C07D 401/ 14^{( . )}
C07D 491/ 04^{( . )}

A61K 31/ 10^{( . )}
A61K 31/ 19^{( . )}
A61K 31/ 34^{( . )}
A61K 31/ 38^{( . )}
A61K 31/ 40^{( . )}
A61K 31/ 404^{( . )}
A61P 29/ 00^{( . )}
A61P 43/ 00^{( . )}
C07C 59/ 68^{( . )}
C07C 69/ 734^{( . )}
C07C 323/ 62^{( . )}
C07D 215/ 14^{( . )}
C07D 307/ 80^{( . )}
C07D 401/ 12^{( . )}
C07D 417/ 12^{( . )}
C07D 491/ 052^{( . )}

(86)	International application number:
	PCT/US1990/006251

(87)	International publication number:
	WO 1991/006537 (16.05.1991 Gazette 1991/11)

(84)	Designated Contracting States:
	AT BE CH DE DK ES FR GB GR IT LI LU NL SE

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Priority:

27.10.1989 US 19890428260
11.10.1990 US 19900596134

(71)	Applicant: AMERICAN HOME PRODUCTS CORPORATION
	Madison, New Jersey 07940-0874 (US)

(72)	Inventors:
	MUSSER, John, Henry Yardley, PA 19067 (US) KREFT, Anthony, Frank, III Langhorne, PA 19046 (US) FAILLI, Amedeo, Arturo Princeton Junction, NJ 08550 (US) DEMERSON, Christopher, Alexander Kirkland, Quebec H9H 4Z9 (US) SHAH, Uresh, Shantilal Plainsboro, NJ 08536 (US) NELSON, James, Albert Washington Crossing, PA 18977 (US)

(74)	Representative: Connelly, Michael John, et al
	c/o Patent Department Wyeth Laboratories Huntercombe Lane South Taplow Maidenhead Berkshire SL6 0PH Maidenhead Berkshire SL6 0PH (GB)

(54)	SUBSTITUTED INDOLE-, INDENE-, PYRANOINDOLE- AND TETRAHYDROCARBAZOLE- ALKANOIC ACID DERIVATIVES AS INHIBITORS OF PLA 2? AND LIPOXYGENASE