(19)

(11)

EP 0 502 179 A1

(12)

(43) Date of publication: 09.09.1992 Bulletin 1992/37 (21) Application number: 91918871.0 (22) Date of filing: 20.09.1991

(51) International Patent Classification (IPC):  C07K 14/ 16( . ) C12N 15/ 85( . ) (86) International application number: PCT/US1991/006838 (87) International publication number: WO 1992/006212 (16.04.1992 Gazette 1992/09)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB IT LI LU NL SE (30) Priority: 28.09.1990 US 19900589737 (71) Applicant: SMITHKLINE BEECHAM CORPORATION King of Prussia, PA 19406 (US)	(72) Inventors: IVEY-HOYLE, Mona King of Prussia, PA 19406 (US) ROSENBERG, Martin Royersford, PA 19468 (US) (74) Representative: Dalton, Marcus Jonathan William, et al  SmithKline Beecham plc Corporate Intellectual Property SB House Great West Road Brentford, Middlesex TW8 9BD Brentford, Middlesex TW8 9BD (GB)