(19)
(11) EP 0 502 897 A1

(12)

(43) Date of publication:
16.09.1992 Bulletin 1992/38

(21) Application number: 90917383.0

(22) Date of filing: 09.11.1990
(51) International Patent Classification (IPC): 
A61K 38/ 00( . )
A61P 29/ 00( . )
C07K 14/ 52( . )
C07K 19/ 00( . )
G01N 33/ 68( . )
A61K 49/ 00( . )
C07K 14/ 435( . )
C07K 14/ 54( . )
G01N 33/ 53( . )
(86) International application number:
PCT/US1990/006580
(87) International publication number:
WO 1991/008483 (13.06.1991 Gazette 1991/13)
(84) Designated Contracting States:
AT BE CH DE ES FR GB GR IT LI LU NL

(30) Priority: 29.11.1989 US 19890442786

(71) Applicant: BRIGHAM AND WOMEN'S HOSPITAL
Boston, MA 02115 (US)

(72) Inventors:
  • GIMBRONE, Michael, A., Jr.
    Jamaica Plain, MA 02130 (US)
  • WHEELER, Margaret, Elyse
    Hot Springs, AZ 71913 (US)

(74) Representative: Sheard, Andrew Gregory 
Kilburn & Strode 30, John Street
London WC1N 2DD
London WC1N 2DD (GB)

   


(54) ENDOTHELIAL-DERIVED IL-8