(19)

(11)

EP 0 503 050 A1

(12)

(43) Date of publication: 16.09.1992 Bulletin 1992/38 (21) Application number: 91918221.0 (22) Date of filing: 26.09.1991

(51) International Patent Classification (IPC):  A61K 38/ 00( . ) A61P 7/ 00( . ) C07K 14/ 505( . ) C07K 14/ 53( . ) C07K 14/ 54( . ) C12N 5/ 10( . ) C12N 15/ 24( . ) C12R 1/ 91( . ) A61K 38/ 22( . ) C07K 14/ 00( . ) C07K 14/ 52( . ) C07K 14/ 535( . ) C07K 19/ 00( . ) C12N 15/ 09( . ) C12P 21/ 02( . ) (86) International application number: PCT/US1991/007053 (87) International publication number: WO 1992/006116 (16.04.1992 Gazette 1992/09)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IT LI LU NL SE (30) Priority: 28.09.1990 US 19900589958 (71) Applicant: ORTHO PHARMACEUTICAL CORPORATION Raritan, NJ 08869-0602 (US)	(72) Inventor: ROSEN, Jonathan, I. San Diego, CA 92131 (US) (74) Representative: Fisher, Adrian John, et al  CARPMAELS & RANSFORD 43 Bloomsbury Square London WC1A 2RA London WC1A 2RA (GB)