(19)

(11)

EP 0 504 136 A1

(12)

(43) Date of publication: 23.09.1992 Bulletin 1992/39 (21) Application number: 90902970.0 (22) Date of filing: 07.12.1989

(51) International Patent Classification (IPC):  A61K 39/ 395( . ) A61K 47/ 48( . ) (86) International application number: PCT/US1989/005539 (87) International publication number: WO 1991/008773 (27.06.1991 Gazette 1991/14)

(84) Designated Contracting States: AT BE CH DE ES FR GB IT LI LU NL SE (71) Applicant: THE CENTER FOR BLOOD RESEARCH Boston, MA 02115 (US)	(72) Inventors: BOREL, Halina Brookline, MA 02146 (US) BOREL, Yves Brookline, MA 02146 (US) (74) Representative: Deans, Michael John Percy, et al  Lloyd Wise, Tregear & CO. Norman House 105-109 Strand London WC2R OAE London WC2R OAE (GB)