(19)

(11)

EP 0 506 814 A1

(12)

(43) Date of publication: 07.10.1992 Bulletin 1992/41 (21) Application number: 91901844.0 (22) Date of filing: 20.12.1990

(51) International Patent Classification (IPC):  A61K 31/ 495( . ) A01N 63/ 02( . ) C07D 471/ 22( . ) C07D 519/ 00( . ) C12P 17/ 18( . ) A01N 43/ 90( . ) A61P 33/ 10( . ) C07D 491/ 22( . ) C12N 1/ 20( . ) C12R 1/ 80( . ) (86) International application number: PCT/GB1990/001997 (87) International publication number: WO 1991/009961 (11.07.1991 Gazette 1991/15)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IT LI LU NL SE (30) Priority: 21.12.1989 GB 19890028844 14.11.1990 GB 19900024716 (71) Applicant: Beecham Group p.l.c. Brentford Middlesex TW8 9BD (GB)	(72) Inventors: BANKS, Rhona, Mary SmithKline Tadworth Surrey KT20 7NT (GB) BLANCHFLOWER, Simon, Edward SmithKline Tadworth Surrey KT20 7NT (GB) READING, Christopher SmithKline Tadworth Surrey KT20 7NT (GB) (74) Representative: West, Vivien, et al  SmithKline Beecham plc Corporate Intellectual Property SB House Great West Road Brentford, Middlesex TW8 9BD Brentford, Middlesex TW8 9BD (GB)