(19)

(11)

EP 0 506 854 A1

(12)

(43) Date of publication: 07.10.1992 Bulletin 1992/41 (21) Application number: 91902540.0 (22) Date of filing: 21.12.1990

(51) International Patent Classification (IPC):  A61K 38/ 00( . ) A61K 39/ 395( . ) C07K 14/ 005( . ) C07K 14/ 21( . ) C07K 16/ 00( . ) C12N 15/ 09( . ) G01N 33/ 53( . ) A61K 39/ 00( . ) A61P 35/ 00( . ) C07K 14/ 195( . ) C07K 14/ 41( . ) C07K 19/ 00( . ) C12P 21/ 02( . ) C12R 1/ 19( . ) (86) International application number: PCT/US1990/007464 (87) International publication number: WO 1991/009965 (11.07.1991 Gazette 1991/15)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IT LI LU NL SE (30) Priority: 21.12.1989 US 19890454162 (71) Applicant: THE UNITED STATES OF AMERICA as represented by the Secretary UNITED STATES DEPARTMENT OF COMMERCE Washington, DC 20002 (US)	(72) Inventors: PASTAN, Ira, H. Potomac, MD 20854 (US) FITZGERALD, David Silver Spring, MD 20902 (US) (74) Representative: Jump, Timothy John Simon, et al  Venner Shipley & Co. 20 Little Britain London EC1A 7DH London EC1A 7DH (GB)