(19)

(11)

EP 0 506 890 A1

(12)

(43) Date of publication: 07.10.1992 Bulletin 1992/41 (21) Application number: 91904350.0 (22) Date of filing: 19.12.1990

(51) International Patent Classification (IPC):  A61K 38/ 00( . ) A61P 5/ 12( . ) C07K 14/ 00( . ) C07K 14/ 72( . ) C07K 16/ 28( . ) C12N 15/ 09( . ) C12P 21/ 08( . ) G01N 33/ 564( . ) C12R 1/ 91( . ) A61K 39/ 395( . ) A61P 37/ 00( . ) C07K 14/ 705( . ) C07K 16/ 00( . ) C12N 5/ 10( . ) C12P 21/ 02( . ) G01N 33/ 53( . ) G01N 33/ 76( . ) (86) International application number: PCT/US1990/007387 (87) International publication number: WO 1991/009137 (27.06.1991 Gazette 1991/14)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IT LI LU NL SE (30) Priority: 20.12.1989 US 19890451973 30.08.1990 US 19900575018 (71) Applicant: NICHOLS INSTITUTE DIAGNOSTICS Los Angeles, California 90009-2797 (US)	(72) Inventor: Rapoport, Basil Greenbrae, CA 94904 (US) (74) Representative: Jaenichen, Hans-Rainer, Dr.  Vossius & Partner, Postfach 86 07 67 D-81634 München D-81634 München (DE)