(19)

(11)

EP 0 509 066 A1

(12)

(43) Date of publication: 21.10.1992 Bulletin 1992/43 (21) Application number: 91916208.0 (22) Date of filing: 09.09.1991

(51) International Patent Classification (IPC):  A61K 31/ 195( . ) (86) International application number: PCT/US1991/006545 (87) International publication number: WO 1992/004023 (19.03.1992 Gazette 1992/07)

(84) Designated Contracting States: CH DE FR GB LI NL (30) Priority: 10.09.1990 US 19900580127 (71) Applicant: SHUG, Austin L. Madison, WI 53704 (US)	(72) Inventor: SHUG, Austin L. Madison, WI 53704 (US) (74) Representative: SERJEANTS  25, The Crescent King Street Leicester, LE1 6RX Leicester, LE1 6RX (GB)