(19)

(11)

EP 0 510 018 A1

(12)

(43) Date of publication: 28.10.1992 Bulletin 1992/44 (21) Application number: 91901263.0 (22) Date of filing: 27.12.1990

(51) International Patent Classification (IPC):  C07K 1/ 107( . ) C12N 15/ 62( . ) C07K 14/ 485( . ) C12N 15/ 70( . ) (86) International application number: PCT/CA1990/000460 (87) International publication number: WO 1991/009952 (11.07.1991 Gazette 1991/15)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IT LI LU NL SE (30) Priority: 26.12.1989 US 19890456473 (71) Applicant: HER MAJESTY IN RIGHT OF CANADA AS REPRESENTED BY THE NATIONAL RESEARCH COUNCIL OF CANADA Ottawa Ontario K1A 0R6 (CA)	(72) Inventors: LAU, Peter Kirkland, Quebec H9H 3J4 (CA) RIOUX, Clément Montreal, Quebec H3X 3P4 (CA) (74) Representative: Durand, Yves Armand Louis, et al  CABINET WEINSTEIN 20, Avenue de Friedland F-75008 Paris F-75008 Paris (FR)