1-AZETIDYL AND 1-HEXAMETHYLENIMINE ALKYL OR ARYL BISPHOSPHONIC ACIDS AND THEIR USE AS PHARMACOLOGICAL AGENTS

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EP 0 510 066 A1

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(43)	Date of publication:
	28.10.1992 Bulletin 1992/44

(21)	Application number: 91902492.0

(22)	Date of filing: 03.01.1991

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International Patent Classification (IPC):

A61K 31/ 675^{( . )}
A61P 3/ 14^{( . )}
A61P 43/ 00^{( . )}
C07F 9/ 40^{( . )}
C07F 9/ 568^{( . )}

A61P 3/ 00^{( . )}
A61P 29/ 00^{( . )}
C07F 9/ 38^{( . )}
C07F 9/ 553^{( . )}
C07F 9/ 6561^{( . )}

(86)	International application number:
	PCT/US1991/000055

(87)	International publication number:
	WO 1991/010646 (25.07.1991 Gazette 1991/17)

(84)	Designated Contracting States:
	AT BE CH DE DK ES FR GB GR IT LI LU NL SE

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Priority:

12.01.1990 US 19900464423

(71)	Applicant: RHONE-POULENC RORER INTERNATIONAL (HOLDINGS) INC.
	Lewes, Delaware 19958 (US)

(72)	Inventors:
	YOUSSEFYEH, Raymond, D. Princeton Junction, NJ 19002 (US) CHENEY, Daniel, L. Audubon, PA 19403 (US) BURNS, Christopher, J. Bryn Mawr, PA 19010 (US)

(74)	Representative: Le Pennec, Magali, et al
	RHONE-POULENC RORER SA, Direction des Brevets, 20 Avenue Raymond Aron F-92165 Antony Cédex F-92165 Antony Cédex (FR)

(54)	1-AZETIDYL AND 1-HEXAMETHYLENIMINE ALKYL OR ARYL BISPHOSPHONIC ACIDS AND THEIR USE AS PHARMACOLOGICAL AGENTS