(19)

(11)

EP 0 511 311 A1

(12)

(43) Date of publication: 04.11.1992 Bulletin 1992/45 (21) Application number: 91904150.0 (22) Date of filing: 17.01.1991

(51) International Patent Classification (IPC):  C12N 5/ 10( . ) C12N 15/ 09( . ) C12P 21/ 02( . ) C12R 1/ 92( . ) C12N 7/ 01( . ) C12N 15/ 867( . ) C12R 1/ 91( . ) (86) International application number: PCT/US1991/000357 (87) International publication number: WO 1991/010728 (25.07.1991 Gazette 1991/17)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IT LI LU NL SE (30) Priority: 19.01.1990 US 19900467791 (71) Applicant: UNITED STATES GOVERNMENT as represented by THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES Bethesda, MD 20878 (US)	(72) Inventors: EGLITIS, Martin Kensington, MD 20895 (US) THOMPSON, J., Anthony Birmingham, AL 35223 (US) ANDERSON, W., French Bethesda, MD 20817 (US) (74) Representative: LOUIS, PÖHLAU, LOHRENTZ & SEGETH  Postfach 3055 D-90014 Nürnberg D-90014 Nürnberg (DE)