(19)

(11)

EP 0 511 366 A1

(12)

(43) Date of publication: 04.11.1992 Bulletin 1992/45 (21) Application number: 92900463.0 (22) Date of filing: 20.09.1991

(51) International Patent Classification (IPC):  C07D 219/ 04( . ) C07D 401/ 06( . ) C07D 409/ 12( . ) C07F 9/ 64( . ) C07D 221/ 12( . ) C07D 405/ 12( . ) C07D 521/ 00( . ) G01N 33/ 58( . ) (86) International application number: PCT/US1991/006861 (87) International publication number: WO 1992/009580 (11.06.1992 Gazette 1992/13)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IT LI LU NL SE (30) Priority: 21.11.1990 US 19900616486 (71) Applicant: BECKMAN INSTRUMENTS, INC. Fullerton, CA 92634 (US)	(72) Inventors: REDDY, M., Parameswara Brea, CA 92621 (US) MICHAEL, Maged, Aziz Brea, CA 92621 (US) OH, Chan, S. Diamond Bar, CA 91765 (US) DOBASHI, Thomas, S. Rosemead, CA 91770 (US) GIRGIS, Nabih, S. Garden Grove, CA 92643 (US) (74) Representative: Ede, Eric  Fitzpatricks, 4 West Regent Street Glasgow G2 1RS, Scotland Glasgow G2 1RS, Scotland (GB)