(19)

(11)

EP 0 514 520 A1

(12)

(43) Date of publication: 25.11.1992 Bulletin 1992/48 (21) Application number: 92900958.0 (22) Date of filing: 01.11.1991

(51) International Patent Classification (IPC):  A61K 8/ 00( . ) A61K 8/ 36( . ) A61K 8/ 41( . ) A61K 8/ 66( . ) A61K 8/ 22( . ) A61K 8/ 365( . ) A61K 8/ 44( . ) A61Q 11/ 02( . ) (86) International application number: PCT/US1991/008107 (87) International publication number: WO 1992/010165 (25.06.1992 Gazette 1992/14)

(84) Designated Contracting States: BE DE DK ES FR GB GR IT (30) Priority: 05.12.1990 US 19900622887 (71) Applicant: WARNER-LAMBERT COMPANY Morris Plains New Jersey 07950 (US)	(72) Inventor: EOGA, Anthony, B., J. Boonton, NJ 07005 (US) (74) Representative: Silbiger, Jakob, Dr.  c/o CAPSUGEL AG Fabrikmattenweg 2-4 CH-4144 Arlesheim CH-4144 Arlesheim (CH)