(19)

(11)

EP 0 515 546 A1

(12)

(43) Date of publication: 02.12.1992 Bulletin 1992/49 (21) Application number: 91905207.0 (22) Date of filing: 11.02.1991

(51) International Patent Classification (IPC):  A61K 31/ 41( . ) A61P 9/ 12( . ) C07D 249/ 08( . ) C07D 249/ 12( . ) C07D 403/ 12( . ) A61P 7/ 10( . ) A61P 43/ 00( . ) C07D 249/ 10( . ) C07D 249/ 14( . ) (86) International application number: PCT/US1991/000963 (87) International publication number: WO 1991/011909 (22.08.1991 Gazette 1991/19)

(84) Designated Contracting States: CH DE FR GB IT LI NL (30) Priority: 13.02.1990 US 19900479779 (71) Applicant: MERCK & CO. INC. Rahway New Jersey 07065-0900 (US)

(72) Inventors: GREENLEE, William, J. Teaneck, NJ 07666 (US) PATCHETT, Arthur, A. Westfield, NJ 07090 (US) HANGAUER, David East Amherst, NY 14051 (US) ASHTON, Wallace Clark, NJ 07030 (US) FITCH, Kenneth, J. Cranford, NJ 07016 (US) WALSH, Thomas Westfield, NJ 07090 (US) RIVERO, Ralph, A. Eatontown, NJ 07724 (US) DHANOA, Daljit, S. Tinton Falls, NJ 07724 (US) (74) Representative: Thompson, John Dr., et al  Merck & Co., Inc. European Patent Department Terlings Park Eastwick Road Harlow, Essex CM20 2QR Harlow, Essex CM20 2QR (GB)