(19)
(11) EP 0 515 548 A1

(12)

(43) Date of publication:
02.12.1992 Bulletin 1992/49

(21) Application number: 91905216.0

(22) Date of filing: 11.02.1991
(51) International Patent Classification (IPC): 
A61K 31/ 415( . )
A61P 9/ 12( . )
A61P 15/ 00( . )
A61P 43/ 00( . )
C07D 233/ 60( . )
C07D 233/ 64( . )
C07D 233/ 68( . )
C07D 403/ 10( . )
C07D 403/ 14( . )
C07F 9/ 6558( . )
 A61P 9/ 00( . )
A61P 13/ 02( . )
A61P 27/ 02( . )
C07D 233/ 58( . )
C07D 233/ 61( . )
C07D 233/ 66( . )
C07D 403/ 06( . )
C07D 403/ 12( . )
C07F 9/ 6506( . )
(86) International application number:
PCT/US1991/001001
(87) International publication number:
WO 1991/012002 (22.08.1991 Gazette 1991/19)
(84) Designated Contracting States:
CH DE FR GB IT LI NL

(30) Priority: 13.02.1990 US 19900479780

(71) Applicant: MERCK & CO. INC.
Rahway New Jersey 07065-0900 (US)

(72) Inventors:
  • GREENLEE, William, J.
    Teaneck, NJ 07666 (US)
  • PATCHETT, Arthur, A.
    Westfield, NJ 07090 (US)
  • HANGAUER, David
    East Amherst, NY 14051 (US)
  • WALSH, Thomas, F.
    Westfield, NJ 07090 (US)
  • FITCH, Kenneth, J.
    Hoboken, NJ 07030 (US)
  • RIVERO, Ralph, A.
    Cliffwood Beach, NJ 07735 (US)
  • DHANOA, Daljit, S.
    Tinton Falls, NJ 07724 (US)

(74) Representative: Thompson, John Dr., et al 
Merck & Co., Inc. European Patent Department Terlings Park Eastwick Road
Harlow, Essex CM20 2QR
Harlow, Essex CM20 2QR (GB)

   


(54) IMIDAZOLE ANGIOTENSIN II ANTAGONISTS INCORPORATING A SUBSTITUTED BENZYL ELEMENT