(19)

(11)

EP 0 516 721 A1

(12)

(43) Date of publication: 09.12.1992 Bulletin 1992/50 (21) Application number: 91905182.0 (22) Date of filing: 20.02.1991

(51) International Patent Classification (IPC):  C07K 14/ 44( . ) C07K 14/ 445( . ) C12N 15/ 09( . ) A61K 39/ 00( . ) C12R 1/ 90( . ) C07K 14/ 00( . ) C12N 1/ 21( . ) C12P 21/ 02( . ) C12R 1/ 19( . ) (86) International application number: PCT/US1991/001059 (87) International publication number: WO 1991/013161 (05.09.1991 Gazette 1991/21)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IT LI LU NL SE (30) Priority: 22.02.1990 US 19900483516 (71) Applicant: THE UNITED STATES OF AMERICA as represented by the Secretary UNITED STATES DEPARTMENT OF COMMERCE Washington, DC 20002 (US)	(72) Inventors: WATERS, Paul, Andrew Rockville, MD 20851 (US) McCUTCHAN, Thomas, F. Rockville, MD 20850 (US) (74) Representative: Perry, Robert Edward  GILL JENNINGS & EVERY Broadgate House 7 Eldon Street London EC2M 7LH London EC2M 7LH (GB)