(19)

(11)

EP 0 517 768 A1

(12)

(43) Date of publication: 16.12.1992 Bulletin 1992/51 (21) Application number: 91905143.0 (22) Date of filing: 26.02.1991

(51) International Patent Classification (IPC):  C07K 14/ 54( . ) C12N 5/ 10( . ) C12N 15/ 85( . ) C12N 1/ 21( . ) C12N 15/ 09( . ) (86) International application number: PCT/US1991/001078 (87) International publication number: WO 1991/013160 (05.09.1991 Gazette 1991/21)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IT LI LU NL SE (30) Priority: 28.02.1990 US 19900486571 (71) Applicant: SCHERING CORPORATION Kenilworth New Jersey 07033 (US)	(72) Inventors: MOORE, Kevin, W. Palo Alto, CA 94304 (US) ZAVODNY, Paul, J. Mountainside, NJ 07092 (US) (74) Representative: Ritter, Stephen David (GB), et al  Mathys & Squire 100 Grays Inn Road GB-London WC1X 8AL GB-London WC1X 8AL (GB)