(19)
(11) EP 0 517 909 A1

(12)

(43) Date of publication:
16.12.1992 Bulletin 1992/51

(21) Application number: 92904304.0

(22) Date of filing: 23.12.1991
(51) International Patent Classification (IPC): 
A61K 35/ 407( . )
C07K 14/ 635( . )
C12N 5/ 071( . )
A61K 38/ 00( . )
 A61K 48/ 00( . )
C07K 14/ 705( . )
C12N 15/ 867( . )
(86) International application number:
PCT/US1991/009700
(87) International publication number:
WO 1992/012242 (23.07.1992 Gazette 1992/19)
(84) Designated Contracting States:
AT BE CH DE DK ES FR GB GR IT LI LU MC NL SE

(30) Priority: 26.12.1990 US 19900633688

(71) Applicants:
  • WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH
    Cambridge, MA 02142 (US)
  • HOWARD HUGHES MEDICAL CENTER
    Bethesda, MD 20817 (US)

(72) Inventors:
  • MULLIGAN, Richard, C.
    Lincoln, MA 01773 (US)
  • WILSON, James, M.
    Ann Arbor, MI 48103 (US)

(74) Representative: Holdcroft, James Gerald, Dr. 
Graham Watt & Co., Riverhead
Sevenoaks, Kent TN13 2BN
Sevenoaks, Kent TN13 2BN (GB)

   


(54) MODIFIED HEPATOCYTES AND USES THEREFOR