(19)

(11)

EP 0 518 902 A1

(12)

(43) Date of publication: 23.12.1992 Bulletin 1992/52 (21) Application number: 91904921.0 (22) Date of filing: 21.02.1991

(51) International Patent Classification (IPC):  C12N 9/ 18( . ) C12P 7/ 62( . ) C12P 7/ 04( . ) C12R 1/ 80( . ) (86) International application number: PCT/GB1991/000275 (87) International publication number: WO 1991/013162 (05.09.1991 Gazette 1991/21)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IT LI LU NL SE (30) Priority: 01.03.1990 GB 19900004647 (71) Applicants: Beecham Group p.l.c. Brentford Middlesex TW8 9BD (GB) GRINTER, Trevor John Tonbridge, Kent TN11 9AN (GB)	(72) Inventors: GRINTER, Trevor, John, SmithKline Beecham Tonbridge, Kennt TN11 9AN (GB) SIME, John, Thomas, SmithKline Beecham Betchworth, Surrey RH3 7AJ (GB) WORONIECKI, Stefan, Roland Betchworth, Surrey RH3 7AJ (GB) (74) Representative: Tocher, Pauline  SmithKline Beecham plc Corporate Intellectual Property SB House Great West Road Brentford, Middlesex TW8 9BD Brentford, Middlesex TW8 9BD (GB)